Weghorn Lab

Evolutionary Processes Modeling

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Preprints

[article] Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes. bioRxiv. (2024)
Arenillas, C., ..., Weghorn, D., ..., Toledo, R.

[article] Mutational signature decomposition with deep neural networks reveals origins of clock-like processes and hypoxia dependencies. bioRxiv. (2023)
Serrano Colome*, C., Canal Anton*, O., Seplyarskiy, V. and Weghorn, D.

[article] The stochastic speed of coming down from infinity for general Dirichlet Xi-coalescents. arXiv. (2022)
Casanova, A. G., Miro Pina, V., Schertzer, E. and Siri-Jegousse, A.

Publications

[article] An extension of the Walsh-Hadamard transform to calculate and model epistasis in genetic landscapes of arbitrary shape and complexity. PLoS Comp. Biol. (2024)
Faure, A., Lehner, B., Miro Pina, V., Serrano Colome, C. and Weghorn, D.

[article] The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability. Journal of Experimental & Clinical Cancer Research. (2024)
Abad, E., Sandoz, J., Romero, G., Urgel-Solas, J., Borredat, P., Kourtis, S., Ortet, L., Martinez, C., Weghorn, D., Sdelci, S. and Janic, A.

[article] High-density sampling reveals volume growth in human tumours. eLife (reviewed preprint). (2024)
Angaji, A., Owusu, M., Velling, C., Dick, N., Weghorn, D. and Berg, J.

[article] Estimating the Lambda measure in multiple-merger coalescents. Theoretical Population Biology, 154, 94-101. (2023) vbioRxiv
Miro Pina, V., Joly, E. and Siri-Jegousse, A.

[article] Genes enriched in A/T-ending codons are co-regulated and conserved across mammals. Cell Systems, 2405-4712. (2023) vbioRxiv
Benisty, H., Hernandez-Alias, X., Weber, M., Anglada-Girotto, M., Mantica, F., Radusky, L., Senger, G., Calvet, F., Weghorn, D., Irimia, M., Schaefer, M. and Serrano, L.

[article] Segregational instability of multicopy plasmids: A population genetics approach. Ecology and Evolution, 12(12), e9469. (2022)
Hernandez-Beltran, J. C. R., Miro Pina, V., Siri-Jegousse, A., Palau, S., Pena-Miller, R. and Gonzalez-Casanova, A.

[article] Germline de novo mutation rates on exons versus introns in humans. Nature Communications, 11(1), 3304. (2020) vbioRxiv
Rodriguez-Galindo, M., Casillas, S., Weghorn, D. and Barbadilla, A.

[article] Identification of cancer driver genes based on nucleotide context. Nature Genetics, 52, 208-218. (2020) vbioRxiv
Dietlein*, F., Weghorn*, D., Taylor-Weiner, A., Richters, A., Reardon, B., Liu, D., Lander, E. S., Van Allen, E. M. and Sunyaev, S. R.

[article] Applicability of the mutation-selection balance model to population genetics of heterozygous protein-truncating variants in humans. Molecular Biology and Evolution, 36.8, 1701. (2019) vbioRxiv
Weghorn*, D., Balick*, D. J., Cassa, C., Kosmicki, J., Daly, M. J., Beier, D. R. and Sunyaev, S. R.

[reply] Reply to 'Selective effects of heterozygous protein-truncating variants'. Nature Genetics, 51(1), 3. (2019)
Cassa*, C. A., Weghorn*, D., Balick*, D. J., Jordan*, D. M., Nusinow, D., Samocha, K. E., O'Donnell-Luria, A., MacArthur, D. G., Daly, M. J., Beier, D. R. and Sunyaev, S. R.

[article] Bayesian inference of negative and positive selection in human cancers. Nature Genetics, 49(12), 1785. (2017) vSharedIt
Weghorn, D. and Sunyaev, S.

[article] Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer. Nature Communications, 8(1), 436. (2017)
D'Antonio*, M., Weghorn*, D., D'Antonio-Chronowska, A., Coulet, F., Olson, K. M., DeBoever, C., Drees, F., Arias, A., Alakus, H., Richardson, A. L., Schwab, R. B., Farley, E. K., Sunyaev, S. R. and Frazer, K. A.

[article] Estimating the selective effects of heterozygous protein-truncating variants from human exome data. Nature Genetics, 49(5), 806. (2017) vPMC
Cassa*, C. A., Weghorn*, D., Balick*, D. J., Jordan*, D. M., Nusinow, D., Samocha, K. E., O'Donnell-Luria, A., MacArthur, D. G., Daly, M. J., Beier, D. R. and Sunyaev, S. R.

[article] Fitness landscape for nucleosome positioning. Proceedings of the National Academy of Sciences, 110(27), 10988-10993. (2013)
Weghorn, D. and Lässig, M.

*equal author contributions; (co-)corresponding author