Evolutionary Processes Modeling
The Weghorn Lab is located at the Centre for Genomic Regulation (CRG) in Barcelona, Spain. Our research focuses on analyzing evolving systems, particularly cancer tumors and the human population. We analyze sequencing and other biological datasets and develop mathematical and computational approaches to estimate selection. An important aspect of this effort is to investigate mutational processes and the heterogeneity of the mutation rate.
We are part of the Joint Program on Evolutionary Medical Genomics.
Also check out our BlueSky account: WeghornLab
...or follow us on Twitter: @WeghornLab
February 2025 | In this preprint, we provide a new perspective on mutational signatures in mismatch-repair-deficient cells. |
February 2025 | Happy to announce that our study on a mutational hotspot at transcription start sites in the human germline finally sees the light of the preprint. |
January 2025 | Welcome to the lab, Javier and Nica! |
December 2024 | Another doctor in the lab. Congrats, Hossam! |
November 2024 | In our collaboration with the great people from the Berg Group, we found tumors characterized by volume growth. |
October 2024 | Clàudia becomes Dr. Serrano Colomé. Enhorabona! |
October 2024 | Maria joins the lab, welcome! |
June 2024 | Check out our fun collaboration with the Toledo Lab on the impact of systemic hypoxia on tumor evolution. |
May 2024 | In this collaboration with the Lehner Lab, we explored multi-state epistasis. |
April 2024 | Check out our collaboration with the Janic Lab on the role of RNF144B for tumor evolution. |
December 2023 | Our SigNet preprint has posted, in which we provide a method for mutational signature decomposition based on deep learning. |